Insights into determinants of spleen injury in sickle cell anemia
Abstract: Spleen dysfunction is central to morbidity and mortality in children with sickle cell anemia (SCA).The initiation and determinants of spleen injury, including acute splenic sequestration (ASS) have not been established.We investigated splenic function longitudinally in a cohort of 57 infants with SCA enrolled at 3 to 6 months of age and f